| Title | Star As | Genre | Info |
|---|---|---|---|
| The Drew Barrymore Show | Herself - Host | - | - |
| The Stand-In | Candy | - | - |
| Santa Clarita Diet | Sheila | TV | - |
| First Dates | Narrator (voice) | TV | - |
| Odd Mom Out | Meredith | TV | - |
| Miss You Already | Jess | - | - |
| Blended | Lauren Reynolds | - | aka "The Familymoon" |
| Big Miracle | Rachel Kramer | - | aka "Everybody Loves Whales" |
| Going the Distance | Erin | - | - |
| Everybody's Fine | Rosie | - | - |
| Grey Gardens | 'Little' Edith Bouvier Beale | - | - |
| He's Just Not That Into You | Mary Harris | - | - |
| Whip It! | Smashley Simpson | - | - |
| Beverly Hills Chihuahua | Chloe (voice) | - | aka South of the Border |
| Lucky You | Billie Offer | - | - |
| Music and Lyrics | Sophie Fisher | - | - |
| Curious George | Miss Maggie Dunlop (voice) | - | - |
| Family Guy | Jillian Russell (voice) | TV | aka Padre de familia |
| Fever Pitch | Lindsey Meeks | - | - |
| 50 First Dates | Lucy Whitmore | - | - |
| Charlie's Angels: Full Throttle | Dylan Sanders | - | - |
| Duplex | Nancy Kendricks | - | aka Our House |
| Confessions of a Dangerous Mind | Penny | - | aka Confessions d'un homme dangereux (Canada: French title) |
| Donnie Darko | Karen Pomeroy | - | - |
| Freddy Got Fingered | Mr. Davidson's Receptionist | - | - |
| Riding in Cars with Boys | Beverly D'Onofrio | - | - |
| Charlie's Angels | Dylan Sanders | - | aka 3 Engel fur Charlie (Germany) |
| Skipped Parts | Fantasy Girl | - | aka The Wonder of Sex |
| Titan A.E | Akima (voice) | - | aka Titan: After Earth |
| Never Been Kissed | Josie Geller | - | - |
| Olive, the Other Reindeer | Olive (voice) | TM | - |
| Saturday Night Live | Herself (Host) / Abigail Breslin / Various | TV | - |
| Ever After | Danielle De Barbarac | - | - |
| Home Fries | Sally Jackson | - | - |
| The Wedding Singer | Julia Sullivan | - | - |
| Best Men | Hope | - | - |
| Wishful Thinking | Lena | - | - |
| Everyone Says I Love You | Schuyler Dandridge | - | - |
| Scream | Casey Becker | - | - |
| Batman Forever | Sugar | - | aka Forever |
| Boys on the Side | Holly Pulchik-Lincoln | - | aka Avec ou sans hommes (France) |
| Mad Love | Casey Roberts | - | - |
| Bad Girls | Lilly Laronette | - | - |
| Inside the Goldmine | Daisy | - | - |
| Doppelganger | Holly Gooding | - | aka Doppelganger: The Evil Within |
| No Place to Hide | Tinsel Hanley | - | - |
| The Amy Fisher Story | Amy Fisher | TM | aka Beyond Control |
| Wayne's World 2 | Bjergen Kjergen | - | - |
| 2000 Malibu Road | Lindsay Rule | TV | - |
| Guncrazy | Anita Minteer | - | - |
| Poison Ivy | Ivy | - | - |
| Sketch Artist | Daisy | TM | - |
| Waxwork II: Lost in Time | Vampire Victim #1 | - | aka Space Shift: Waxwork II |
| Motorama | Fantasy Girl | - | - |
| 15 and Getting Straight | Susan | TM | - |
| Far from Home | Joleen Cox | - | - |
| See You in the Morning | Cathy Goodwin | - | - |
| A Conspiracy of Love | Jody Woldarski | TM | - |
| Babes in Toyland | Lisa Piper | TM | - |
| Star Fairies | Hillary (voice) | TV | - |
| Cat's Eye | Amanda | - | aka Stephen King's Cat's Eye |
| The Adventures of Con Sawyer and Hucklemary Finn | Con Sawyer | TM | - |
| Firestarter | Charlene 'Charlie' McGee | - | - |
| Irreconcilable Differences | Casey Brodsky | - | - |
| E.T. the Extra-Terrestrial | Gertie | - | aka E.T. the Extra- Terrestrial: The 20th Anniversary |
| Altered States | Margaret Jessup | - | - |
| Bogie | Leslie Bogart | TM | - |
| Suddenly, Love | Bobby Graham | TM | - |