| Title | Star As | Genre | Info |
|---|---|---|---|
| High Expectations | Jack's Father | - | - |
| Trollhunters: Rise of the Titans | Blinky (voice) | - | - |
| Charming the Hearts of Men | - | - | - |
| Miss Willoughby and the Haunted Bookshop | - | - | - |
| Money Plane | Darius Emmanuel Grouch | - | - |
| The God Committee | - | - | - |
| Grand Isle | Detective Jones | - | - |
| Proven Innocent | Gore Bellows | TV | - |
| The Space Between (2019) | Micky Adams | - | - |
| 7 Guardians of the Tomb | Mason | - | aka "Nest" |
| Like Father | - | - | - |
| Bunyan and Babe | Norm Blandsford (voice) | - | - |
| Storks | Hunter (voice) | - | - |
| The Last Tycoon | Pat Brady | TV | - |
| Trollhunters | Blinky (voice) | TV | - |
| Baby, Baby, Baby | Sebastian | - | - |
| Best of Enemies | Himself | - | - |
| Breaking the Bank | Charles | - | - |
| Killing Jesus | King Herod | - | - |
| Partners (2014) | Allen Braddock | TV | - |
| Reach Me | Angelo AldoBrandini | - | - |
| The Expendables 3 | Bonaparte | - | - |
| Think Like a Man Too | Lee Fox | - | - |
| Transformers: Age of Extinction | Harold Attinger | - | aka "Transformers 4" |
| Heart Transplant with Kelsey Grammer (Short) | - | - | - |
| Legends of Oz: Dorothy's Return | Tin Man (voice) | - | - |
| Boss | Mayor Thomas Kane | TV | - |
| I Don't Know How She Does It | Clark Cooper | - | - |
| Crazy on the Outside | Frank | - | - |
| Fame | Joel Cranston | - | - |
| Hank | Hank Pryor | TV | - |
| Middle Men | Frank Griffin | - | - |
| An American Carol | General George S. Patton | - | - |
| Back to You Season 1: This Just In | Chuck Darling | VI | - |
| Behind the Headlines: The Making of 'Back to You' | Chuck Darling | VI | - |
| Swing Vote | President Andrew Boone | - | - |
| The Simpsons Ride | Sideshow Bob (voice) | - | - |
| Back to You | Chuck Darling | TV | - |
| The Simpsons Game | Sideshow Bob (voice) | VG | - |
| Even Money | Detective Brunner | - | - |
| X-Men: The Last Stand | Dr. Henry 'Hank' McCoy / Beast | - | aka X-Men 3 |
| Kelsey Grammer Presents: The Sketch Show | Various | TV | - |
| The Good Humor Man | Mr. Skibness | - | - |
| A Christmas Carol | Ebenezer Scrooge | TM | aka A Christmas Carol: The Musical |
| Frasier: Analyzing the Laughter | Dr. Frasier Crane | TM | aka Analyzing the Laughter |
| Teacher's Pet | Dr. Ivan Krank (voice) | - | aka Disney's Teacher's Pet |
| Barbie of Swan Lake | Rothbart (voice) | VI | - |
| Benedict Arnold: A Question of Honor | George Washington | TM | - |
| The Big Empty | Agent Banks | - | - |
| Mr. St. Nick | Nick St. Nicholas/Santa Claus the 21st | TM | aka Monsieur St-Nick (Canada: French title) |
| 15 Minutes | Robert Hawkins | - | aka 15 Minuten Ruhm (Germany) |
| The Sports Pages | Howard Greene | TM | - |
| Gary the Rat | Gary 'The Rat' Andrews (voice) | VI | - |
| Animal Farm | Snowball (voice) | TM | - |
| Bartok the Magnificent | Zozi (voice) | VI | - |
| Mickey's Once Upon a Christmas | Narrator (voice) | VI | - |
| New Jersey Turnpikes | - | - | - |
| Standing on Fishes | Verk | - | - |
| Toy Story 2 | Stinky Pete the Prospector (voice) | - | aka Toy Story 2 in 3-D |
| The Pentagon Wars | Maj. Gen. Partridge | TM | - |
| The Real Howard Spitz | Howard Spitz | - | aka Samantha et Monsieur Spitz (Canada: French title) |
| Anastasia | Vladimir (voice) | - | - |
| Fired Up | Tom Whitman | TV | - |
| Down Periscope | Lt. Cmdr. Thomas 'Tom' Dodge | - | - |
| London Suite | Sydney Nichols | TM | aka Neil Simon's London Suite |
| Runaway Brain | Dr. Frankenollie (voice) | - | - |
| The Innocent | Det. Frank Barlow | TM | - |
| Beyond Suspicion | Ron McNally | TM | aka Appointment for a Killing |
| Frasier | Dr. Frasier Crane | TV | - |
| Galaxies Are Colliding | Peter | - | aka Planet of Love |
| The Simpsons | Sideshow Bob | TV | - |
| Top of the Hill | - | TM | - |
| Dance 'Til Dawn | Ed Strull | TM | - |
| Mickey's 60th Birthday | Dr. Frasier Crane | TM | aka Mickey's 60th Birthday Anniversary Shorts Programme |
| Paul Reiser Out on a Whim | - | TM | - |
| Crossings | Craig Lawson | TV | - |
| Cheers | Dr. Frasier Crane | TV | - |
| George Washington | Lt. Stewart | TV | - |
| Kennedy | Stephen Smith | TV | - |
| Macbeth | Ross | TV | - |
| Another World | Dr. Canard | TV | aka Another World: Bay City |