| Title | Star As | Genre | Info |
|---|---|---|---|
| Delia's Gone | - | - | aka "Caged Bird Sing" |
| Human Capital | Carrie | - | - |
| The King of Staten Island | Margie | - | aka "Untitled Judd Apatow Comedy Project" |
| Avengers: Endgame | Aunt May | - | - |
| Frankie | Irene | - | aka "A Family Vacation" |
| Spider-Man: Far From Home | Aunt May | - | - |
| After Everything | Dr. Lisa Harden | - | aka "Shotgun" |
| Behold My Heart | Margaret Lang | - | - |
| Citizen Jane: Battle for the City | Narrator (voice) | - | - |
| Laboratory Conditions | Emma Holloway | - | - |
| Spider-Man: Homecoming | Aunt May | - | - |
| Captain America: Civil War | May Parker | - | - |
| Empire | Mimi Whiteman | TV | - |
| Love the Coopers | Emma | - | aka "The Most Wonderful Time" |
| Ms. | Gloria Steinem | TV | - |
| The Big Short | Cynthia Baum | - | - |
| Trainwreck | Marisa Tomei | - | - |
| Loitering with Intent | Dominic's sister | - | aka "Why Now?!" |
| Love Is Strange | Kate | - | - |
| Spare Parts | Gwen | - | aka "La Vida Robot" |
| The Rewrite | Holly Carpenter | - | aka "Untitled Marc Lawrence Project" |
| She Said, She Said | Marishka | - | - |
| Inescapable | Fatima | - | - |
| Jason Alexander Joins the 99% | - | - | - |
| Parental Guidance | Alice Simmons | - | aka "Us & Them" |
| Crazy, Stupid, Love. | Kate | - | - |
| Salvation Boulevard | Honey Foster | - | - |
| The Ides of March | Ida Horowicz | - | - |
| The Lincoln Lawyer | Maggie McPherson | - | - |
| Cyrus | Molly | - | - |
| Amsterdam | Donna | VI | - |
| The Wrestler | Cassidy | - | - |
| War, Inc. | Natalie Hegalhuzen | - | aka Brand Hauser: Stuff Happens |
| Before the Devil Knows You're Dead | Gina | - | - |
| Wild Hogs | Maggie | - | - |
| Danika | Danika | - | - |
| Loverboy | Sybil | - | - |
| Factotum | Laura | - | - |
| Marilyn Hotchkiss' Ballroom Dancing and Charm School | Meredith Morrison | - | - |
| Alfie | Julie | - | - |
| Game Over | Raquel Smashenburn (voice) | TV | - |
| Anger Management | Linda | - | - |
| Just a Kiss | Paula | - | - |
| The Guru | Lexi | - | aka Gourou et les femmes, Le (France) |
| The Wild Thornberrys Movie | Bree Blackburn (voice) | - | - |
| In the Bedroom | Natalie Strout | - | - |
| Jenifer | Nina Capelli | TM | - |
| Someone Like You | Liz | - | aka Animal Attraction |
| Dirk and Betty | Paris | - | - |
| Happy Accidents | Ruby Weaver | - | - |
| King of the Jungle | Det. Costello | - | - |
| The Watcher | Dr. Polly Beilman | - | - |
| What Women Want | Lola | - | - |
| My Own Country | Mattie Vines | TM | - |
| Only Love | Evie | TM | - |
| Since You've Been Gone | Tori | TM | - |
| Slums of Beverly Hills | Rita Abromowitz | - | - |
| A Brother's Kiss | Missy | - | - |
| Welcome to Sarajevo | Nina | - | - |
| Unhook the Stars | Monica Warren | - | aka D�croche les �toiles (France) |
| Four Rooms | Margaret | - | - |
| The Perez Family | Dorita Evita Perez | - | - |
| Only You | Faith Corvatch | - | aka Just in Time |
| The Paper | Martha Hackett | - | - |
| Untamed Heart | Caroline | - | - |
| Chaplin | Mabel Normand | - | aka Charlot (Italy) |
| Equinox | Rosie Rivers | - | aka Isimeria |
| My Cousin Vinny | Mona Lisa Vito | - | - |
| Oscar | Lisa Provolone | - | - |
| Zandalee | Remy | - | - |
| Parker Kane | April Haynes | TM | - |
| A Different World | Maggie Lauten | TV | - |
| Supermom's Daughter | Noelle Crandall | TM | - |
| Playing for Keeps | Tracy | - | - |
| The Toxic Avenger | Health Club Girl | - | - |
| The Flamingo Kid | Mandy | - | - |
| As the World Turns | Marcy Thompson Cushing | TV | - |