| Title | Star As | Genre | Info |
|---|---|---|---|
| The Stand | Mother Abagail | TV | - |
| Pierre the Pigeon-Hawk | Pierre's Mother (voice) | - | - |
| Furlough | - | - | - |
| Ghetto Plainsman | Zaures | - | - |
| Instinct | Joan Ross | TV | - |
| Nobody's Fool | - | - | aka "The List" |
| Floyd Norman: An Animated Life | Herself | - | - |
| King of the Dancehall | Loretta Brixton | - | - |
| Yamasong: March of the Hollows | Yari | - | - |
| A Warrior's Tail | Mama Zho Zi (voice) (version: English) | - | - |
| Black Dog, Red Dog | Calliope | - | - |
| Delores and Jermaine | Delores | TM | - |
| A Day Late and a Dollar Short | Viola | - | - |
| Big Stone Gap | Fleeta | - | - |
| Misery Loves Comedy | Herself | - | - |
| Sensitive Men | Spiritual Leader | TM | - |
| Teenage Mutant Ninja Turtles | Bernadette Thompson | - | - |
| Top Five | Herself | - | aka "Finally Famous" |
| Moms Mabley: I Got Somethin' to Tell You | Herself | - | - |
| Glee | Carmen Tibideaux | TV | - |
| Late Night with Jimmy Fallon | Lady Whoopi | TV | - |
| The Contradictions of Fair Hope | - | - | - |
| A Little Bit of Heaven | God | - | - |
| For Colored Girls | Alice/White | - | aka "For Colored Girls Who Have Considered Suicide When the Rainbow Is Enuf" |
| Toy Story 3 | Stretch the Octopus (voice) | - | - |
| Toy Story 3: The Video Game | Stretch (voice) | VG | - |
| Stream | Jodi | - | - |
| The Little Engine That Could | Tower | - | - |
| A Muppets Christmas: Letters to Santa | Taxi Driver | TM | - |
| Descendants | Red Flower (voice) | - | - |
| Snow Buddies | Miss Mittens | VI | - |
| If I Had Known I Was a Genius | Mom | - | - |
| Doogal | Ermintrude (voice) | - | - |
| Everybody Hates Chris | Louise | TV | - |
| Everyone's Hero | Darlin' (voice) | - | - |
| Farce of the Penguins | Helen (voice) | VI | - |
| Homie Spumoni | Thelma | - | aka "It's Under My Skin" |
| Racing Stripes | Franny (voice) | - | - |
| The Magic Roundabout | Ermintrude | - | aka Sprung! The Magic Roundabout |
| The View | Herself - Host | TV | - |
| Littleburg | Mayor Whoopi | TV | aka Whoopi's Littleburg |
| Pinocchio 3000 | Cyberina (voice) | - | aka PK3: Pinocho 3000 (Spain) |
| The Lion King 1� | Shenzi (voice) | VI | aka Lion King 3: Hakuna Matata! |
| Blizzard | Blizzard (voice) | - | - |
| Good Fences | Mabel Spader | TM | - |
| It's a Very Merry Muppet Christmas Movie | Daniel's 'Boss' | TM | - |
| Liberty's Kids: Est. 1776 | Deborah Samson aka Robert Shurtleff | TV | - |
| Madeline: My Fair Madeline | Miss Clavel (voice) | TM | - |
| Star Trek: Nemesis | Guinan | - | - |
| Call Me Claus | Lucy Cullins | TM | - |
| Golden Dreams | Calafia, the Queen of California (Narrator) | - | - |
| Kingdom Come | Raynelle Slocumb | - | - |
| Monkeybone | Death | - | - |
| Rat Race | Vera Baker | - | aka Course folle (Canada: French title) |
| The Hollywood Sign | One of the women throwing dirt on coffin at funeral scene | - | aka Himmel von Hollywood, Der (Germany) |
| The Mark Twain Prize: Whoopi Goldberg | - | TM | - |
| What Makes a Family | Terry Harrison | TM | - |
| More Dogs Than Bones | Cleo | - | - |
| The Adventures of Rocky & Bullwinkle | Judge Cameo | - | aka Abenteuer von Rocky und Bullwinkle, Die (Germany) |
| Alice in Wonderland | Cheshire Cat | - | aka Alice im Wunderland (Germany) |
| Foxbusters | (voice) | TV | - |
| Girl, Interrupted | Valerie Owens, RN | - | aka Durchgeknallt (Germany) |
| Jackie's Back! | Nurse Ethyl Washington Rue Owens (Jackie's Sister) | TM | aka Jackie's Back: Portrait of a Diva |
| Our Friend, Martin | Mrs. Peck (voice) | VI | - |
| The Deep End of the Ocean | Candy Bliss | - | - |
| The Magical Legend of the Leprechauns | The Grand Banshee | TM | aka Kampf der Kobolde (Germany) |
| A Knight in Camelot | Dr. Vivien Morgan | TM | - |
| Alegr�a | Baby Clown | - | - |
| How Stella Got Her Groove Back | Delilah Abraham | - | - |
| Rudolph the Red-Nosed Reindeer: The Movie | Stormella, The Evil Ice Queen (voice) | - | - |
| The Rugrats Movie | Ranger Margaret (voice) | - | - |
| Titey | The Iceberg | - | - |
| A Christmas Carol | Spirit of Christmas Present (voice) | - | - |
| Cinderella | Queen Constantina | - | aka Rodgers & Hammerstein's Cinderella |
| Destination Anywhere | Cabbie | - | - |
| In the Gloaming | Nurse Myrna | - | - |
| Mother Goose: A Rappin' and Rhymin' Special | Mother Gooseberg (voice) | TM | - |
| Bogus | Harriet Franklin | - | - |
| Bordello of Blood | Hospital Patient | - | aka Tales from the Crypt Presents: Bordello of Blood |
| Eddie | Edwina 'Eddie' Franklin | - | - |
| Ghosts of Mississippi | Myrlie Evers | - | aka Ghosts from the Past |
| The Associate | Laurel Ayres | - | - |
| Boys on the Side | Jane Deluca | - | aka Avec ou sans hommes (France) |
| Happily Ever After: Fairy Tales for Every Child | Mother Goose | TV | - |
| Moonlight and Valentino | Sylvie Morrow | - | - |
| The Sunshine Boys | Nurse | TM | - |
| Theodore Rex | Katie Coltrane | VI | aka T. Rex |
| A Cool Like That Christmas | Mom/Irwin (voice) | TM | - |
| Corrina, Corrina | Corrina Washington | - | - |
| Star Trek: Generations | Guinan | - | aka Star Trek 7 |
| The Lion King | Shenzi the Hyena (voice) | - | - |
| The Little Rascals | Buckwheat's Mom | - | - |
| The Pagemaster | Fantasy (voice) | - | - |
| Loaded Weapon 1 | Sgt. Billy York | - | aka National Lampoon's Loaded Weapon 1 |
| Made in America | Sarah Mathews | - | - |
| Naked in New York | Tragedy Mask on Theater Wall | - | - |
| Sister Act 2: Back in the Habit | Deloris Van Cartier/Sister Mary Clarence | - | - |
| Yuletide in the 'hood | (voice) | TM | - |
| Defenders of Dynatron City | Ms. Megawatt (voice) | TM | - |
| Sarafina! | Mary Masembuko | - | - |
| Sister Act | Deloris Van Cartier/Sister Mary Clarence | - | - |
| The Player | Detective Susan Avery | - | - |
| Blackbird Fly | - | - | - |
| Soapdish | Rose Schwartz | - | - |
| Bagdad Cafe | Brenda | TV | - |
| Captain Planet and the Planeteers | Gaia | TV | aka The New Adventures of Captain Planet |
| Ghost | Oda Mae Brown | - | - |
| Tales from the Whoop: Hot Rod Brown Class Clown | - | TM | aka Hot Rod Brown, Class Clown |
| The Long Walk Home | Odessa Cotter | - | - |
| Comicitis | - | - | - |
| Homer and Eddie | Eddie Cervi | - | - |
| Kiss Shot | Sarah Collins | TM | - |
| My Past Is My Own | Mariah Johnston | TV | - |
| Clara's Heart | Clara Mayfield | - | - |
| The Telephone | Vashti Blue | - | - |
| Burglar | Bernice 'Bernie' Rhodenbarr | - | - |
| Fatal Beauty | Rita Rizzoli | - | - |
| Jumpin' Jack Flash | Terry Dolittle | - | - |
| The Color Purple | Celie | - | - |
| Citizen | - | - | - |